Fundamental Sulfur (MSM®) tablets provided by Advanced Medical Nutrition, each contain 500 mg of methylsulfonyl-methane (MSM). MSM, a derivative of DMSO, is a naturally occurring compound of biologically available sulfur. The essential trace element molybdenum is added as a cofactor for normal sulfur metabolism. Fundamental Sulfur also provides vitamin C, while Fundamental Sulfur II does not.

Sulfur is an indispensable element in human nutrition. As part of the amino acids methionine and cysteine, sulfur is required for the structural integrity and function of almost every protein in the body, including enzymes, serum proteins, and the keratin of skin, hair, and nails. Taurine, another sulfur-containing amino acid is known for its role in bile salt synthesis, cell membrane stability, neuronal excitability and the regulation of osmotic pressure. Sulfur is also an essential element for the glycosaminoglycans of connective tissues and cartilage, and assumes a major role in detoxification as part of the hepatic sulfur conjugation pathways. Proper detoxification of xenobiotics, such as phenols, and many endogenous and foreign food- or airborne compounds depends on an adequate supply of biologically active sulfur. Dietary MSM serves as a versatile donor of metabolically active sulfur for the synthesis of numerous organosulfur compounds and proteins in the body. As such, MSM helps maintain normal immune response, lung function, connective tissue metabolism, and muscle contraction. MSM occurs naturally in a variety of foods, such as fruits, vegetables, cereal grains, milk, and fish. However, MSM is volatile and easily lost during cooking. MSM is very well absorbed by the intestinal tract and rapidly distributed within the body. Molybdenum is an essential trace element that assists in the proper metabolism of sulfur. Specifically, molybdenum is the cofactor of sulfite oxidase, an enzyme that converts potentially toxic sulfite to sulfate. This reaction is necessary for the normal metabolism of the sulfur amino acids.

Other Ingredients

cellulose, magnesium stearate, and silicon dioxide.

Suggested Use

The suggested dose is one tablet three times daily, or as directed by a physician.

Does Not Contain

corn; wheat; soya; sugar or other sweeteners; artificial flavors, colors or preservatives.

Warnings/Cautions

No significant side effects reported. Fundamental Sulfur is odorless and does not produce the characteristic gas or body odor which often occurs with other forms of sulfur. MSM is safe and well tolerated even in amounts as high as 20 grams per day (40 tablets). Some individuals may experience transitory detoxification symptoms. Those intolerant to ascorbic acid should use Fundamental Sulfur II which is free of vitamin C.